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Effect of an extract of the mushroom Agaricus blazei Murill on expression of adhesion molecules and production of reactive oxygen species in monocytes and granulocytes in human whole blood ex vivo
Acciones de Documento
An extract of the medicinal mushroom Agaricus blazei Murill differentially stimulates production of pro-inflammatory cytokines in human monocytes and human vein endothelial cells in vitro
2005 - Un extracto de la seta medicinal Agaricus blazei Murill estimula diferenciadamente la producción de citoquinas proinflamatorias en monocitos humanos y células endoteliales de las venas humanas in vitro.
Palabras clave:
Interleukin-12,
Interleukin-10,
monocytes - monocitos,
Interleukin-1Beta,
Interleukin-6,
Interleukin-8,
Tumor Necrosis Factor alpha - factor de necrosis tumoral alfa
- Inflammation. 2005 Dec;29(4-6):147-53.
An extract of the medicinal mushroom Agaricus blazei Murill differentially stimulates production of pro-inflammatory cytokines in human monocytes and human vein endothelial cells in vitro.
Bernardshaw S, Hetland G, Ellertsen LK, Tryggestad AM, Johnson E.
Department of Gastroenterological Surgery, Ulleval University Hospital, Kirkeveien 166, 0407 Oslo, Norway.
An extract of the edible mushroom Agaricus blazei Murill (AbM) has known antitumor and anti-infection properties, probably mainly by stimulating mononuclear phagocytes of the native immune system. The aim of this work was to study the effect of AbM on the production by human monocytes and human umbilical vein endothelial cells (EC) of pro-inflammatory cytokines (IL-1beta, IL-6, IL-8, TNFalpha), the anti-inflammatory/T regulatory cytokine IL-10 and the pro-Th1 cytokine IL-12. AbM, in concentrations from 1-15%, induced a considerable and dose-dependent increase in production of IL-8, IL-6, TNFalpha and IL-1beta in monocyte cultures. The biosynthesis reached a plateau at a concentration of 10% of AbM, and was most pronounced for the three former cytokines. AbM did also dose-dependently stimulate EC production of IL-8,I L-6 and TNFalpha, but at lower levels compared with the monocytes. AbM did neither induce synthesis of cytokines IL-10 nor IL-12 in monocytes or EC. Our results demonstrate the differential effect of AbM stimulation on the magnitude of pro-inflammatory cytokines produced by monocytes and EC.
Dos nuevos trabajos científicos citados en Pubmed sobre las actividades antioxidantes, antimutagénicas y anti-hepatoma del Agaricus blazei