¿Ha olvidado su contraseña?
¿Nuevo usuario?
Todas las páginas de contenido de AbM.objectis.net
Resumen de literatura científica de alto índice de impacto sobre el Agaricus blazei Murill o champiñón del Sol
Acciones de Documento
Antigenotoxicity of Agaricus blazei mushroom organic and aqueous extracts in chromosomal aberration and cytokinesis block micronucleus assays in CHO-k1 and HTC cells
2006 - Antigenotoxicidad del Agaricus blazei y extractos acuosos en aberraciones cromosómicas y bloqueo de citocinesis de micronúcleos en CHO-K1 y de las células HTC.
Palabras clave:
antimutagenic - antimutagénico,
anticlastogenicity - anticlastogenidad
- Toxicol In Vitro. 2006 Apr;20(3):355-60. Epub 2005 Sep 22.
Antigenotoxicity of Agaricus blazei mushroom organic and aqueous extracts in chromosomal aberration and cytokinesis block micronucleus assays in CHO-k1 and HTC cells.
Bellini MF, Angeli JP, Matuo R, Terezan AP, Ribeiro LR, Mantovani MS.
Departamento de Biologia Geral, Universidade Estadual de Londrina-Campus Universitário, Cx. Postal 6001, 86051990 Londrina, PR, Brazil.
Agaricus blazei (Ab) has become popularly known for its medicinal properties. Scientifically, it has been tested with regard to its capacity to protect genetic material against damage. We examined different organic extracts (methanolic extract -- ME, hexanic extract -- HE and n-butanolic extract -- BE) and an aqueous extract (AE) of Ab, for their capacity to induce DNA damage as well as for their protective effect. Genetic damage was determined by the chromosomal aberration assay (CA) in CHO-k1 cells for all extracts and the cytokinesis block micronucleus assay (CBMN) in non drug-metabolizing (CHO-k1) and drug-metabolizing (HTC) cell lines for extract BE only. The extracts did not show clastogenicity but showed anticlastogenicity. The greatest percent reduction obtained were with BE (105%) and AE (126%) treatments in CA. BE treatment did not display genotoxicity in CHO-k1, but was genotoxic in HTC. However, BE was shown to be antigenotoxic causing decreased micronucleus frequency in HTC and CHO-k1 cells. These results suggest that all the extracts contained protective substances, but in some cases they could show a genotoxic effect with regard to metabolism. Therefore, these findings warrant caution in the use of this mushroom by the population.
Un nuevo trabajo sobre el potencial tremendo de un polisacárido de bajo peso molecular del Agaricus blazei en el tratamiento de metástasis neoplásicas y gruesos errores de la publicidad de muchos sitios sobre este champiñón del sol