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Resumen de literatura científica de alto índice de impacto sobre el Agaricus blazei Murill o champiñón del Sol
Acciones de Documento
Antihypertensive Effect of .GAMMA.-Aminobutyric Acid-Enriched Agaricus blazei on Spontaneously Hypertensive Rats
2002 - Efecto antihipertensivo del Agaricus blazei enriquecido con ácido gamma amniobutírico en ratas hipertensivas espontáneamente
Palabras clave:
hypertension - hipertensión
Antihypertensive Effect of .GAMMA.-Aminobutyric Acid-Enriched Agaricus blazei on Spontaneously Hypertensive Rats.
| Accession number;02A0331152 |
| Title;Antihypertensive Effect of .GAMMA.-Aminobutyric Acid-Enriched Agaricus blazei on Spontaneously Hypertensive Rats. |
| Author;WATANABE TOSHIRO(Himeji Inst. Technol., School Of Humanities for Enviromental Policy and Technol., JPN) YAMADA TAKAKO(Himeji Inst. Technol., School Of Humanities for Enviromental Policy and Technol., JPN) TANAKA HITOKO(Himeji Inst. Technol., School Of Humanities for Enviromental Policy and Technol., JPN) JIANG S(Yaegakihakkogiken) MAZUMDER T K(Yaegakihakkogiken) NAGAI SHIRO(Yaegakihakkogiken) TSUJI KEISUKE(Himeji Inst. Technol., School Of Humanities for Enviromental Policy and Technol., JPN) |
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Journal Title;Journal of the Japanese Society for Food Science and Technology |
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Journal Code:F0895A |
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ISSN:1341-027X |
| VOL.49;NO.3;PAGE.166-173(2002) |
| Figure&Table&Reference;FIG.6, TBL.3, REF.32 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The effect of .GAMMA.-aminobutyric acid (GABA)-enriched Agaricus blazei (AG-GABA) and mycelia of Agaricus blazei (AG-M) on blood pressure of spontaneously hypertensive rats (SHR) was studied. Powdered AG-GABA or AG-M was fed on SHR at the levels of 5% (Experiment-A) or 2% (Experiment-B) in a 1% NaCl (control) diet for 21 or 28 days and that systolic and diastolic blood pressure were measured by tail cuff. Animals of AG-GABA and AG-M groups showed significantly lower blood pressure compared to the control group. AG-GABA had stronger hypotensive effect than AG-M. The serum levels of total cholesterol (TC) and triglyceride of groups fed AG-GABA and AG-M were lower than those of the control group, and atherogenic index [(TC-HDL-C)/HDL-C] was improved in 21 or 28 days. The inhibitory activity of the angiotensin I-converting enzyme (ACE) was compared among of AG-GABA, AG-M and GABA. The IC50 of AG-GABA and AG-M for ACE were 1.9 and 1.7 mg/ml, respectively. However, GABA showed no inhibitory activity against the ACE. These phenomena suggested that AG-GABA has concomitant hypotensive effects by GABA and ACE inhibitory substance (unknown). (author abst.) |
Dos nuevos trabajos científicos sobre los mecanismos de la apóptosis y actividad antimetastática inducidos por Agaricus blazei Murill o champiñón del sol