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Efectos tumoricidas de los beta-glucanos: los mecanismos incluyen tanto actividad antioxidante como la suma de un una inmunidad sistémica y tópica
Acciones de Documento
Delayed Cell Cycle Progression and Apoptosis Induced by Hemicellulase-Treated Agaricus blazei
2006 - Retardo de la progresión celular y apóptosis inducida por Agaricus blazei tratado con hemicelulosa.
Palabras clave:
Tumor Necrosis Factor alpha - factor de necrosis tumoral alfa
- Evid Based Complement Alternat Med. 2007 Mar;4(1):83-94. Epub 2006 Sep 11.
Delayed Cell Cycle Progression and Apoptosis Induced by Hemicellulase-Treated Agaricus blazei.
Kawamura M, Kasai H.
Department of Alternative Medicine and Bioregulation, Faculty of Medicine and Department of Microbiology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi Yamanashi, Japan.
We examined the effects of hemicellulase-treated Agaricus blazei (AB fraction H, ABH) on growth of several tumor cell lines. ABH inhibited the proliferation of some cell lines without cytotoxic effects. It markedly prolonged the S phase of the cell cycle. ABH also induced mitochondria-mediated apoptosis in different cell lines. However, it had no impact on the growth of other cell lines. ABH induced strong activation of p38 mitogen-activated protein kinase (MAPK) in the cells in which it evoked apoptosis. On the other hand, ABH showed only a weak p38 activation effect in those cell lines in which it delayed cell cycle progression with little induction of apoptosis. However, p38 MAPK-specific inhibitor inhibited both ABH-induced effects, and ABH also caused apoptosis in the latter cells under conditions of high p38 MAPK activity induced by combined treatment with TNF-alpha. These results indicate that the responsiveness of p38 MAPK to ABH, which differs between cell lines, determines subsequent cellular responses on cell growth.
Dos nuevos trabajos científicos citados en Pubmed sobre las actividades antioxidantes, antimutagénicas y anti-hepatoma del Agaricus blazei