¿Ha olvidado su contraseña?
¿Nuevo usuario?
Nuevo experimento con animales sanos, in vivo e in vitro, sobre respuestas inmunitarias inducidas por Agaricus blazei Murill o champiñón del sol
Todas las páginas de contenido de AbM.objectis.net
Therapy of myeloma in vivo using marine phospholipid in combination with Agaricus blazei Murill as an immune respond activator
Acciones de Documento
Efectos tumoricidas de los beta-glucanos: los mecanismos incluyen tanto actividad antioxidante como la suma de una inmunidad sistémica y tópica
2008 - Efectos tumoricidas de los beta-glucanos: los mecanismos incluyen tanto actividad antioxidante como la suma de una inmunidad sistémica y tópica (Tumoricidal Effects of beta-Glucans: Mechanisms Include Both Antioxidant Activity Plus Enhanced Systemic and Topical Immunity)
- Nutr Cancer. 2008;60(5):685-91.
-
Tumoricidal Effects of beta-Glucans: Mechanisms Include Both Antioxidant Activity Plus Enhanced Systemic and Topical Immunity.
Graduate School of Health Science, Suzuka University of Medical Science, Suzuka, Mie, Japan.
A study to evaluate the mechanisms of tumoricidal activity resulting from orally administered extract of Agaricus blazei Murill (A. blazei) was performed in mice bearing syngeneic and xenogeneic tumors. Tumor regression was comparably seen in both syngeneic and xenogeneic tumor-bearing mice when administered oral extract preparations. In addition, in a murine syngeneic tumor model, oral administration of water-soluble extracts of A. blazei resulted in significant production of cytokines such as IFN-gamma, and TNF-alpha in peritoneal exudate cells, in parallel with the marked regression of tumor development. The water-soluble extracts also induced pronounced antioxidant activity in in vitro and in vivo assays using two different methods. These results indicate the A. blazei extract may enhance not only the immnunomodulatory effects that promote activity of peritoneal exudate cells for tumor regression but also potentially result in the direct destruction of tumor cells through its antioxidant activity.
PMID: 18791933 [PubMed - in process]
