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Effect of an extract of the mushroom Agaricus blazei Murill on expression of adhesion molecules and production of reactive oxygen species in monocytes and granulocytes in human whole blood ex vivo
Acciones de Documento
Effects on gene expression and viral load of a medicinal extract from Agaricus blazei in patients with chronic hepatitis C infection
2007 - Efectos sobre la expresión génica y de la carga viral de un extracto medicinal de Agaricus blazei en pacientes con hepatitis C.
Palabras clave:
Hepacivirus,
liver - hígado,
Interferon Type III,
beta glucan - betaglucanos,
Interleukin-12,
Hepatitis C
- Int Immunopharmacol. 2006 Aug;6(8):1311-4. Epub 2006 May 11.
Effects on gene expression and viral load of a medicinal extract from Agaricus blazei in patients with chronic hepatitis C infection.
Grinde B, Hetland G, Johnson E.
Division of Infectious Disease Control, Norwegian Institute of Public Health, Ullevål University Hospital, Oslo, Norway. bjorn.grinde@thi.no
Extracts from the mushroom Agaricus blazei Murill (AbM) are used extensively as a non-prescription remedy against cancer and infections, including hepatitis. We previously demonstrated a potent immunomodulating effect of a particular preparation on monocytes in vitro, and a protective effect on bacterial infections in mice. Here we report the effect on gene expression in peripheral blood cells from four chronic hepatitis C patients, using global (29 k) oligo-based, single channel microarrays. The viral load was slightly, but not significantly, decreased after 1 week of AbM treatment. The cytokine genes most strongly induced in vitro were not induced in vivo. The more notable changes in mRNA levels were related to genes involved in the G-protein coupled receptor signalling pathway, in cell cycling, and in transcriptional regulation. The results suggest that the beta-glucans of the extract, which presumably are responsible for cytokine induction, did not readily enter the blood, while other components, such as substances proposed to have anticancer effects, were active in the blood.
Dos nuevos trabajos científicos citados en Pubmed sobre las actividades antioxidantes, antimutagénicas y anti-hepatoma del Agaricus blazei