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Resumen de literatura científica de alto índice de impacto sobre el Agaricus blazei Murill o champiñón del Sol
Acciones de Documento
Hypotensive Effects and Safety of Extracts Squeezed from Agaricus blazei on High-normal Blood Pressure and Mild Hypertensive Subjects
2006 - Efectos hipotensivos del Agaricus blazei Murill o champiñón del Sol en personas con la tensión elevada o medianamente elevada.
Palabras clave:
hypertension - hipertensión
| Author;KOBAYASHI HITOSHI(Hokuto) INATOMI SATOSHI(Hokuto) OUCHI KENJI(Hokuto) AZUMI YOSHIHITO(Hokuto) TSUCHIDA TAKASHI(Isogochuonoshinkeigekabyoin) |
|
Journal Title;Japanese Pharmacology & Therapeutics |
|
Journal Code:Z0947A |
|
ISSN:0386-3603 |
| VOL.34;NO.12;PAGE.1323-1341(2006) |
| Figure&Table&Reference;FIG.6, TBL.12, REF.24 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;To
investigate hypotensive effects and safety in the long term ingestion
of extracts squeezed from Agaricus blazei(ABFE)containing
.GAMMA.-aminobutyric acid(GABA)which is expected hypotensive effect in
hypertensive persons, we conducted double-blind, placebo-controlled
study on high normal blood pressure and mild hypertensive subjects to
the number of 80(mean age, 46). Group A (n=40)ingested 50mL of placebo
water non-containing GABA as placebo-control, and group B(n=40)ingested
50mL of ABFE containing 40mg of GABA for 12 weeks consecutively. In
group B, systolic blood pressures of high normal blood pressure
subjects decreased significantly at 4 weeks after ingest initiation
compared with that of group A(p<0.01), and diastolic blood pressure
decreased significantly at 8 weeks after ingest initiation compared
with that of group A(p<0.01). In mild hypertensive subjects of group
B, both systolic and diastolic blood pressures decreased significantly
at 6 weeks or 4weeks after ingest initiation compared with those of
group A, respectively(p<0.05, p<0.01, respectively). Furthermore,
when the ABFE ingestion was stopped at 12 weeks after ingest
initiation, systolic and diastolic blood pressures of all subjects in
the group B were increased gradually. In addition, abnormalities in
subjective symptom, interview by medical doctors, blood test,
biochemical test and urinary test were not observed in all of subjects
during the study period. These results suggest that the ABFE containing
40 mg of GABA causes reduction of systolic and diastolic blood
pressures of high normal blood pressure and mild hypertensive persons
in the long-term ingestion, and the ABFE is safety food. |
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