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Therapy of myeloma in vivo using marine phospholipid in combination with Agaricus blazei Murill as an immune respond activator
Acciones de Documento
Immunomodulatory effects of Agaricus blazei Murill in Balb/cByJ mice
2007 - Efectos inmunomoduladores del Agaricus blazei Murill en ratones Balb/cByJ.
Palabras clave:
inmunomodulation - inmunomodulación,
lymphocytes - linfocitos,
spleen - bazo,
T lymphocytes - linfocitos T,
Tumor Necrosis Factor alpha - factor de necrosis tumoral alfa,
splenocytes - esplenocitos
- J Microbiol Immunol Infect. 2007 Jun;40(3):201-8.
Immunomodulatory effects of Agaricus blazei Murill in Balb/cByJ mice.
Chan Y, Chang T, Chan CH, Yeh YC, Chen CW, Shieh B, Li C.
Department of Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan.
BACKGROUND AND PURPOSE: Agaricus blazei Murill has been reported to possess biological effects that include immunomodulatory and tumoricidal activities, but its potential effects have not been systematically analyzed in vivo. We evaluated the immunomodulatory effects of A. blazei in Balb/cByJ mice. METHODS: 160 male Balb/cByJ mice were divided into four groups and treated with various quantities of intragastric A. blazei extract or distilled water for 8 to 10 weeks. Nine parameters, relating to general immune function or adaptive immunity against immunogen chicken oval albumin, were determined. RESULTS: The results revealed that mice receiving A. blazei extract exhibited significantly greater serum immunoglobulin G levels, increased T-cell numbers in spleen, and elevated phagocytic capability compared with controls. Consumption of A. blazei was also associated with significant increases in oval albumin-specific serum immunoglobulin G level, delayed-type hypersensitivity, splenocyte proliferation rate, and tumor necrosis factor-alpha secretion by splenocytes. CONCLUSIONS: Consumption of A. blazei extract was associated with significant enhancement of seven out of nine immune functions tested. We conclude that A. blazei Murill possesses a wide range of immunomodulatory effects in vivo.
Dos nuevos trabajos científicos citados en Pubmed sobre las actividades antioxidantes, antimutagénicas y anti-hepatoma del Agaricus blazei