¿Ha olvidado su contraseña?
¿Nuevo usuario?
Un trabajo muy importante sobre la actividad antidiabética de algunas fracciones de Agaricus blazei o champiñón del sol
Todas las páginas de contenido de AbM.objectis.net
Effects of dietary supplementation with medicinal fungus in fasting glycemia levels of patients with colorectal cancer: a randomized, double-blind, placebo-controlled clinical study
Acciones de Documento
Improvement of pancreatic .BETA.-cells by hot water extract from cultured Agaricus blazei (CJ-01) fruiting bodies in GK rats
2000 - Mejoría de las células pancreáticas BETA por extracto de agua caliente de los cuerpos fructíferos cultivados del Agaricus blazei (CJ-01) en ratas GK.
Palabras clave:
glucose - glucosa,
Pancreas,
Diabetes Mellitus, Type 2,
hypoglicemic - hipoglicemiante,
Diabetes
mprovement of pancreatic .BETA.-cells by hot water extract from cultured Agaricus blazei (CJ-01) fruiting bodies in GK rats.
| Accession number;00A1055343 |
| Title;Improvement of pancreatic .BETA.-cells by hot water extract from cultured Agaricus blazei (CJ-01) fruiting bodies in GK rats. |
| Author;HIGAKI MIYATO(Tokyo Univ. of Agric.) EGUCHI FUMIO(Tokyo Univ. of Agric.) ZHANG J(Shinapusu Kaiken) KIKUKAWA TADAHIRO(St. Marianna Univ.) ABE CHIYUKI(St. Marianna Univ.) KATO KATSUHIKO(Azabu Univ., Sch. of Vet. Med.) HASEGAWA KAZUO(Tokyo Medical College) WATANABE YASUO |
|
Journal Title;Journal of Traditional Medicines |
|
Journal Code:Y0941A |
|
ISSN:1340-6302 |
| VOL.17;NO.5;PAGE.205-214(2000) |
| Figure&Table&Reference;FIG.6, TBL.3, REF.17 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Inhibitory effects of cultured Agaricus blazei (CJ-01) fruit hot water extract on the development of diabetes in spontaneously diabetic rats (GK rats) which are characterized as having non-obese and non-insulin dependent diabetes mellitus (NIDDM) were examined. The increase of plasma glucose level induced by a 20% glucose solution seen in GK was significantly higher than that of normal Wistar rats. The loading of a glucose treatment was constantly performed for 12 weeks. CJ-01 (10 g/600 ml) was extracted at 80.DEG.C. for 1 hr and each dosage (3, 5, 10 g/60 kg/day) was orally given to GK rats. The GK rats were divided into five groups: 1) CJ-01 untreated and glucose loading (control), 2) CJ-01 untreated and non-glucose (non-glu), 3) low dose of CJ-01 (3 g/60 kg/day) treated and glucose loading, 4) middle dose of CJ-01 (5 g/60 kg/day) and glucose loading (middle-CJ), 5) high dose of CJ-01 treated and glucose loading (high-CJ). The development of hyperglycemia induced by glucose was seen in the control animals. In the CJ-01 treated animals, however, the increase of plasma glucose levels were significantly attenuated. Particularly these levels of high-CJ group were much lower than those seen in control group at the 4 th week of the CJ-01 consecutive treatment. In the blood examination, all results were identical, although the significant increase of pancreatic insulin levels were detected in the high-CJ group. Histopathological study revealed evidences that CJ-01 had no effect on number of the islets among the animals. High dose of CJ-01 had increased number of pancreatic .BETA. cells at a significance level of 0.01. It had beneficial effects on foamy cell degeneration, deposition of hyaline-1ike substance, and hypertrophy of the islets. Thus CJ-01 may have therapeutic effects on NIDDM due to the amelioration of the impaired function and the increase of pancreatic .BETA. cells. (author abst.) |
