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Interleukin-12- and interferon-gamma-mediated natural killer cell activation by Agaricus blazei Murill
Acciones de Documento
In vitro augmentation of natural killer activity and interferon-gamma production in murine spleen cells with Agaricus blazei fruiting body fractions
2005 - Aumento in vitro de la actividad de las natural killer y del interferón-gamma en la producción de células de bazo murino con fracciones de cuerpos frutíferos del Agaricus blazei.
Palabras clave:
Interleukin-12,
spleen - bazo,
Natural Killers - células NK,
Interferon Type III,
Interferon Type II
- Biosci Biotechnol Biochem. 2005 Dec;69(12):2466-9.
In vitro augmentation of natural killer activity and interferon-gamma production in murine spleen cells with Agaricus blazei fruiting body fractions.
Zhong M, Tai A, Yamamoto I.
Bizen Chemical Co., Ltd., Okayama, Japan.
Aqueous extracts of the Agaricus blazei fruiting body prepared at different temperatures were fractionated by ethanol precipitation with various ethanol concentrations. The original aqueous extracts of A. blazei failed to stimulate natural killer (NK) cell activity in murine spleen cells in vitro, but the strongest effect was observed in a 30% ethanol-soluble-50% ethanol-insoluble fraction prepared from the extract at 40 degrees C (fraction A-50). Fraction A-50 also showed the strongest augmenting effect on interferon (IFN)-gamma production. This augmentation of NK activity and IFN-gamma production by fraction A-50 was completely abrogated by a heat treatment.
Dos nuevos trabajos científicos citados en Pubmed sobre las actividades antioxidantes, antimutagénicas y anti-hepatoma del Agaricus blazei