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Resumen de literatura científica de alto índice de impacto sobre el Agaricus blazei Murill o champiñón del Sol
Acciones de Documento
Inhibitory effect of Agaricus blazei Murill components on abnormal collagen fiber formation in human hepatocarcinoma cells
2008 - Efecto inhibidor de componentes del Agaricus blazei Murill en la formación de fibra colágena anormal en las células del hepatocarcinoma humano.
- Biosci Biotechnol Biochem. 2008 Feb;72(2):621-3. Epub 2008 Feb 7.
Inhibitory effect of Agaricu blazei Murill components on abnormal collagen fiber formation in human hepatocarcinoma cells.
Sorimachi K, Akimoto K, Koge T.
Educational Support Center, Dokkyo Medical University, Mibu, Tochigi 321-0293, Japan. kenjis@dokkyomed.ac.jp
Hot-water extracts of the mycelial culture and fruiting bodies of Agaricus blazei Murill were fractionated by ethanol precipitation, using various ethanol concentrations. The mycelial fraction (A-4) inhibited abnormal collagen fiber formation, and fractions A-1 to A-3 showed a small inhibitory effect. The strongest inhibition was obtained by fraction A-4, and no significant inhibition was observed with fractions A-5 and A-6. With the fruiting bodies, fractions B-1 to B-6 showed no inhibitory effects on collagen fiber formation in HCC. The reverse transcription-polymerase chain reaction (RT-PCR) demonstrates that Agaricus blazei mycelial fraction A-4 did not inhibit the type I, II or III procollagen gene expression.
Dos nuevos trabajos científicos sobre los mecanismos de la apóptosis y actividad antimetastática inducidos por Agaricus blazei Murill o champiñón del sol