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An extract of the mushroom Agaricus blazei Murill protects against lethal septicemia in a mouse model of fecal peritonitis
Acciones de Documento
Inhibitory effects of Agaricus blazei on mast cell-mediated anaphylaxis-like reactions
2006 - Efectos inhibitorios de Agaricus blazei en las reacciones de las células mediadas de tipo anafiláctico de los mastocitos.
Palabras clave:
mast cells - mastocitos,
inmunoglobulin - inmunoglobulinas,
anaphilaxis - anafilaxis,
calcium - calcio
- Biol Pharm Bull. 2006 Jul;29(7):1366-71.
Inhibitory effects of Agaricus blazei on mast cell-mediated anaphylaxis-like reactions.
Choi YH, Yan GH, Chai OH, Choi YH, Zhang X, Lim JM, Kim JH, Lee MS, Han EH, Kim HT, Song CH.
Department of Anatomy, Chonbuk National University Medical School, Jeonbuk, Republic of Kora.
Agaricus blazei is a medicinal mushroom native to Brazil. It used to be a source of anti-tumor and immunmoactive compounds and considered a health food in many countries. However, its specific effect against mast cell-mediated anaphylactic reactions is still unknown. In the present study, we investigated the effect of Agaricus blazei water extract (ABWE) on mast cell-mediated anaphylaxis-like reactions. We examined whether ABWE could inhibit systemic anaphylaxis-like reaction, ear swelling response, passive cutaneous anaphylaxis, and mast cell activation. ABWE inhibited compound 48/80-induced systemic anaphylaxis-like reaction, ear swelling response, and passive cutaneous anaphylaxis-like reaction in mice. ABWE also inhibited anti-dinitrophenyl (DNP) IgE-mediated passive cutaneous anaphylaxis. ABWE dose-dependently inhibited compound 48/80-induced or anti-DNP IgE-mediated histamine release from rat peritoneal mast cells (RPMC). Moreover, pretreatment with ABWE reduced compound 48/80-induced calcium uptake into RPMC. When ABWE was added, the level of intracellular cAMP in RPMC showed a significant increase compared with that of control cells. In addition, ABWE significantly inhibited compound 48/80-induced cAMP reduction in RPMC. These results propose that ABWE may be beneficial in the treatment of mast cell-mediated anaphylactic reactions.
Dos nuevos trabajos científicos citados en Pubmed sobre las actividades antioxidantes, antimutagénicas y anti-hepatoma del Agaricus blazei