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Resumen de literatura científica de alto índice de impacto sobre el Agaricus blazei Murill o champiñón del Sol
Acciones de Documento
Inhibitory effects of hot water extract from Agaricus blazei fruiting bodies (CJ-01) on hypertension development in Spontaneously Hypertensive Rats
1999 - Efectos inhibidores de extractos de agua caliente de los cuerpos fructíferos del Agaricus blazei (CJ-01) en el desarrollo de hipertensión en ratas espontáneamente hipertensivas.
Palabras clave:
hypertension - hipertensión
Inhibitory effects of hot water extract from Agaricus blazei fruiting bodies (CJ-01) on hypertension development in Spontaneously Hypertensive Rats.
| Accession number;00A0165843 |
| Title;Inhibitory effects of hot water extract from Agaricus blazei fruiting bodies (CJ-01) on hypertension development in Spontaneously Hypertensive Rats. |
| Author;EGUCHI FUMIO(Tokyo Univ. of Agric.) WATANABE YASUO(Tokyo Medical College) ZHANG J(Shinappusu) MIYAMOTO KOJI(Yamaguchi Univ., Sch. of Med.) YOSHIMOTO HIROAKI(Nihombaio) FUKUHARA TOMIO(Tokyo Medical College) HIGAKI MIYATO(Tokyo Univ. of Agric.) |
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Journal Title;Journal of Traditional Medicines |
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Journal Code:Y0941A |
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ISSN:1340-6302 |
| VOL.16;NO.5;PAGE.201-207(1999) |
| Figure&Table&Reference;FIG.2, TBL.3, REF.12 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Inhibitory effects of Agaricus blazei fruit hot water extract (CJ-01) on the development of hypertension in Spontaneously Hypertensive Rats(SHR) were examined. Marked hypertension occurs in 8-week old SHR and a significant increase in hypertension is shown in 10-week old SHR. Maximum hypertension occurs in 20-week old SHR. The development of hypertension seen in SHR was measured by means of the Tail Cuff method and blood/urine examinations. CJ-01 (10g/600ml) was extracted at 80.DEG.C. for 1hr and several dosages (3 to 15g/60kg/day) were freely given to SHR and normotensive (WKY) rats. Animals were divided into five groups: 1) CJ-01 untreated WKY(WKY-Con), 2) CJ-01 treated WKY from 8th week after birth (WKY-Pre), 3) CJ-01 untreated SHR(SHR-Con), 4) CJ-01 treated SHR from 8th week after birth (SHR-Pre), 5) CJ-01 treated SHR from 10th week after birth (SHR-Post). All results obtained from WKY-Con and WKY-Pre were identical, although these data were significantly different from those of SHR-Con. In the SHR-Pre group, dosages between 6 and 12g/60kg/day of CJ-01 significantly blocked the development of hypertension and improved the results of blood and urine examinations, particularly creatinine level, A/G ratio, total cholesterol, urine excretion and so on. Also, the SHR-Post group exhibited a significant reduction in hypertension after 40 days of treatment, although the same dosage did not effect WKY animals. Thus CJ-01 may have prophylactic and/or therapeutic effects on hypertension and hypertensive disease. (author abst.) |
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