¿Ha olvidado su contraseña?
¿Nuevo usuario?
Resumen de literatura científica de alto índice de impacto sobre el Agaricus blazei Murill o champiñón del Sol
Acciones de Documento
Interleukin-12- and interferon-gamma-mediated natural killer cell activation by Agaricus blazei Murill
2007 - 03 - 07. Activación de las células NK mediadas por interleuquina-12 e interferon-gamma por el Agaricus blazei Murill.
Palabras clave:
Natural Killers - células NK,
Interleukin-12,
dentritic cells - células dentríticas,
spleen - bazo,
Interferon Type III,
splenocytes - esplenocitos
- Immunology. 2007 Jun;121(2):197-206. Epub 2007 Mar 7.
Interleukin-12- and interferon-gamma-mediated natural killer cell activation by Agaricus blazei Murill.
Yuminamochi E, Koike T, Takeda K, Horiuchi I, Okumura K.
Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan.
Dried fruiting bodies of Agaricus blazei Murill (A. blazei) and its extracts have generally used as complementary and alternative medicines (CAMs). Here, we report that the oral administration of A. blazei augmented cytotoxicity of natural killer (NK) cells in wild-type (WT) C57BL/6, C3H/HeJ, and BALB/c mice. Augmented cytotoxicity was demonstrated by purified NK cells from treated wild-type (WT) and RAG-2-deficient mice, but not from interferon-gamma (IFN-gamma) deficient mice. NK cell activation and IFN-gamma production was also observed in vitro when dendritic cell (DC)-rich splenocytes of WT mice were coincubation with an extract of A. blazei. Both parameters were largely inhibited by neutralizing anti-interleukin-12 (IL-12) monoclonal antibody (mAb) and completely inhibited when anti-IL-12 mAb and anti-IL-18 mAb were used in combination. An aqueous extract of the hemicellulase-digested compound of A. blazei particle; (ABPC) induced IFN-gamma production more effectively, and this was completely inhibited by anti-IL-12 mAb alone. NK cell cytotoxicty was augmented with the same extracts, again in an IL-12 and IFN-gamma-dependent manner. These results clearly demonstrated that A. blazei and ABPC augmented NK cell activation through IL-12-mediated IFN-gamma production.
Dos nuevos trabajos científicos citados en Pubmed sobre las actividades antioxidantes, antimutagénicas y anti-hepatoma del Agaricus blazei