Suppressive effect of polysaccharides from the edible and medicinal mushrooms, Lentinus edodes and Agaricus blazei, on the expression of cytochrome P450s in mice
2002 - Efecto de supresión de los polisacáridos de las setas comestibles y medicinales, Lentinus edodes y Agaricus blazei, en la expresión del citocromo P450s en ratones.
- Biosci Biotechnol Biochem. 2002 Jul;66(7):1610-4.
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Suppressive effect of polysaccharides from the edible and medicinal mushrooms, Lentinus edodes and Agaricus blazei, on the expression of cytochrome P450s in mice.
Division of Life Science, Graduate School of Science and Technology, Kobe University, Japan.
To investigate the effects of lentinan from Lentinas edodes and polysaccharides from Agaricus blazei (ABPS) on the expression of cytochrome P450s (CYPs), lentinan (10 mg/kg/day) or ABPS (200 mg/kg/day) was administered to female BALB/c mice four times every other day by intraperitoneal injection. Lentinan and ABPS suppressed both the constitutive and 3-methylcholanthrene-induced CYP1A expression and ethoxyresorufin-O-deethylation activity in the liver.

