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Un nuevo sitio sobre información completa y seria acerca del Agaricus blazei Murill o champiñón del Sol
Bcl-2 and caspase-3 are major regulators in Agaricus blazei-induced human leukemic U937 cell apoptosis through dephoshorylation of Akt
Pubmed
Acciones de Documento
The Medicinal Mushroom Agaricus blazei Murrill: Review of Literature and Pharmaco-Toxicological Problems
2008 - La seta medicinal Agaricus blazei Murill: revisión de la literatura y problemas fármaco-toxicológicos.
Palabras clave:
Ergosterol,
Natural Killers - células NK,
Nitric Oxide - oxido nítrico,
hypertension - hipertensión,
leukemia - leucemia,
beta glucan - betaglucanos,
Dermatitis,
antiangiogenic - antiangiogénico,
fat - grasas,
liver neoplasm - neoplasias del hígado,
investigaciones,
genital neoplasm - neoplasias genitales,
antilipemic - antilipémico,
antiviral,
insulin - insulina,
leukocytes - leucocitos,
hypoglicemic - hipoglicemiante,
antigenotoxic - antigenotóxico,
hepatoma,
anticlastogenicity - anticlastogenidad,
distintos tipos,
anticarcinogenic - anticarcinogénico,
Diabetes,
cholesterol - colesterol,
antibiotics - antibióticos,
antioxidant - antioxidante,
historia,
Hepatitis B,
Hepatitis C,
visceral fat - grasas infiltradas,
ovarian neoplasms - neoplasias de ovarios,
Hepacivirus,
cultivo,
antibodies - anticuerpos,
hepatocarcinoma,
Lentinan,
antimutagenic - antimutagénico,
Diabetes Mellitus, Type 2,
antineoplastic - antineoplásico
- Evid Based Complement Alternat Med. 2008 Mar;5(1):3-15.
The Medicinal Mushroom Agaricus blazei Murrill: Review of Literature and Pharmaco-Toxicological Problems.
Firenzuoli F, Gori L, Lombardo G.
Center of Natu
Full text:
eCAM Advance Access originally published online on March 27, 2007
eCAM 2008 5(1):3-15; doi:10.1093/ecam/nem007
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Review |
The Medicinal Mushroom Agaricus blazei Murrill: Review of Literature and Pharmaco-Toxicological Problems
F. Firenzuoli1, L. Gori1 and G. Lombardo21Center of Natural Medicine and 2Department of Internal Medicine, S. Giuseppe Hospital, Az USL 11, Empoli, Italy
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Abstract |
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Agaricus blazei Murrill (ABM) popularly known as ‘Cogumelo do Sol’ in Brazil, or ‘Himematsutake’ in Japan, is a mushroom native to Brazil, and widely cultivated in Japan for its medicinal uses, so it is now considered as one of the most important edible and culinary-medicinal biotechnological species. It was traditionally used to treat many common diseases like atherosclerosis, hepatitis, hyperlipidemia, diabetes, dermatitis and cancer. In vitro and in vivo ABM has shown immunomodulatory and antimutagenic properties, although the biological pathways and chemical substances involved in its pharmacological activities are still not clear. The polysaccharides phytocomplex is thought to be responsible for its immunostimulant and antitumor properties, probably through an opsonizing biochemical pathway. Clinical studies are positive confirmations, but we are still at the beginning, and there are perplexing concerns especially relative to the content of agaritine. Argantine is a well-known carcinogenic and toxic substance in animals, that must be completely and fully evaluated.
Keywords: Agaricus blazei Murrill (ABM) – cancer prevention – immune response – agartine – medicinal mushroom
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Introduction |
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Mushrooms and primarily basidiomycetous fungi are a popular and valuable food, low in calories and high in minerals, essential amino acids, vitamins and fibers (1); some of them produce substances having potential medical effects, and are called medicinal mushrooms. Agaricus blazei Murrill (ABM) is known in Brazil as Cogumelo do sol or medicinel, in Japan as Himematsutake, Agarikusutake or Kawarihiratake and in China as Ji Song Rong. It was brought to Japan due to alleged health effects and is widely used today in Oriental countries both as an edible mushroom, considered a functional food, and as natural therapy in the form of a medicinal extract mostly for prevention and treatment of cancer. In accordance with Brazilian tradition, it would be useful against a variety of diseases like diabetes, atherosclerosis, hepatitis, hypercholesterolemia, heart disease and so on. In Japan, researchers demonstrated immunostimulant and anticancer effects of ABM extracts experimentally, and due to the improving consumption of this mushroom in recent years, a considerable effort investigated the putative effects with interesting, but still insufficient clinical studies. Experimental studies increased commercial interest for ABM because of many requests as popular remedy especially in Japan, stimulating not only the production, but also the registration of new names and brands with new popular names. This makes it difficult for the public to identify pure ABM strains.
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History and Ethnopharmacology |
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Agaricus blazei Murrill is a mushroom originally native to a small village, name Piedade, in the highland areas of Atlantic forest, near Tauape, in the province of Sao Paolo, Brazil. It was discovered in 1960 by Takatoshi Furumoto a grower and researcher who sent it to Japan in 1965 for investigation. It was identified as ABM by the Belgian botanist Heinemann in 1967 (2). Later it was given the common name of Himematsutake in Japan, while in Brazil it was named Cogumelo Piedade. The mushroom is traditionally believed to fight physical and emotional stress, stimulate immune system, improve the quality of life in diabetics, reduce cholesterol, prevent osteoporosis and peptic ulcer, treat circulatory and digestive problems and fight cancer (2). All traditional and not-proved beliefs, as often happens, are intentionally used and publicized on the web and mass media for commercial purposes often without any real scientifically demonstrated clinical benefit for patients (3). Over the last decade, the mushroom has been studied as a novel functional food in Japan, Korea, China and Taiwan. The fruiting bodies are still quite expensive to grow, so a relatively cheap and stable source for commercial purpose is still sought. Medicinal mushrooms have an established history of use in traditional oriental therapies: historically, hot-water soluble fractions from medicinal mushroom were used as medicine in the Far East from where this knowledge and practice seem to have been originated. The first historical description about the use of mushroom of Agaricus genus for medicinal purposes is probably described by Byzantine medical treatises in the Mediterranean area, from the 4th century AD to the 15th century AD by Orivasios and Apuleius for treating malignant ulcers of the larynx (4).
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Botanics |
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